
In 2010, Imperioli signed on to play the lead in the ABC television show Detroit 1-8-7. He was a guest on the "San Giuseppe" episode of Mario Batali's Food Network television show Molto Mario. He is an active member of The Jazz Foundation of America and co-hosted their May 2009 annual benefit concert, "A Great Night in Harlem", at the Apollo Theater, which celebrated the foundation's 20th anniversary.

Imperioli served as artistic director of Studio Dante, an Off-Broadway theater he formed with his wife. He also wrote five episodes for The Sopranos. In addition to his role on The Sopranos, Imperioli has appeared in a number of films, including Goodfellas, Jungle Fever, Bad Boys, Malcolm X, The Basketball Diaries, Clockers, Dead Presidents, Girl 6, My Baby's Daddy, Lean on Me, I Shot Andy Warhol, Last Man Standing, Shark Tale, High Roller: The Stu Ungar Story, and Summer of Sam, which he also co-wrote and co-produced. He won one Emmy for the fifth season of The Sopranos in 2004. Imperioli has been nominated for two Golden Globe Awards and five Emmy Awards for his work as Christopher Moltisanti on The Sopranos. While at Lee Strasberg, he met John Ventimiglia who later portrayed Artie Bucco on The Sopranos, and the two became roommates. At age 17, Imperioli moved to Manhattan's East Village enrolling at Lee Strasberg Theatre and Film Institute to study acting. The night before he was set to begin college he confided in his parents of his desire to be an actor. After graduating from Brewster High School in 1983, Imperioli planned on studying pre-med at the State University of New York at Albany. At age 11, Imperioli and his family moved to Brewster, New York, and in high school he began watching Broadway plays.

His ancestors immigrated to New York from Italy in the 1890s, from Lazio and Sicily.
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He is the son of Dan Imperioli, a bus driver and amateur actor, and Claire Imperioli, a department store worker and amateur actress.

Imperioli was born in Mount Vernon, New York, a working class suburb of New York City. Imperioli is also a screenwriter, co-writing the screenplay for Summer of Sam (1999) with Spike Lee, writing five episodes of The Sopranos, and writing as well as directing the feature film The Hungry Ghosts (2008).
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He has had supporting roles in films such as Jungle Fever (1991), Bad Boys (1995), The Basketball Diaries (1995), Shark Tale (2004) and The Lovely Bones (2009), as well as in the HBO drama series The White Lotus (2021–present). He gained recognition in the early part of his career for his role as Spider in Martin Scorsese's Goodfellas (1990). He is best known for his role as Christopher Moltisanti in the HBO crime drama The Sopranos (1999–2007), which earned him the Primetime Emmy Award for Outstanding Supporting Actor in a Drama Series in 2004. Michael Imperioli (born March 26, 1966) is an American actor, writer, and musician.
